Description(s):
The proto-oncogene human epidermal growth factor receptor 2 (HER2) gene also known as ERBB2 is a member of the ERBB/HER RTK family which is comprised of EGFR (EGFR/HER1/ERBB1), HER3/ERBB3, and HER4/ERBB4. This gene encodes for a transmembrane glycoprotein receptor with an intracellular domain with tyrosine kinase activity which is responsible for the activation of intracellular signal transduction pathways controlling epithelial cell growth, differentiation, and angiogenesis. Aberrations of the HER2 gene which usually leads to increased receptor signaling have been observed in many different types of cancer.
ERBB2 (HER2) S310F lies within the extracellular domain of the Erbb2 (Her2). S310F confers a gain of function to Erbb2 (Her2) as indicated by increased phosphorylation of Erbb2 (Her2) and downstream signaling, colony formation, migration, transformation in cell culture, and enhanced tumor growth.
- The cell line can be used for studying ErbB/HER signaling pathway.
- The cell line can be used for screening or evaluating related drugs/compounds.
- The cell line is viral-vector free.
- Transfected Her2 gene sequence and its expressed protein have been confirmed.
- The cell line is mycoplasma-free.
